Heterogeneity in child and adolescent brain development

Project status:

Profiling intra- and inter-individual differences in child and adolescent brain development

Abstract

Large-scale longitudinal neuroimaging studies offer an unprecedented opportunity for investigating child and adolescent brain development at the population level. Such studies have uncovered group-level trajectories in structural brain development, which cross-sectional research applies to examine differences in brain maturation with respect to psychopathology and cognitive development. While work has focused on untangling individual differences in structural brain development (Mills et al., 2021), uncertainty remains as to how much these trajectories differ between individuals (Becht & Mills, 2020).

Manuscripts

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Bottenhorn KL, Cardenas-Iniguez C, Mills KL, Laird AR, Herting MM. Profiling intra- and inter-individual differences in child and adolescent brain development. 2022. Available from: http://biorxiv.org/content/early/2022/12/20/2022.12.19.521089.abstract

Presentations

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Bottenhorn KL, Herting MM. Individual variability in structural brain development with respect to sex and puberty. Poster presented at: 28th Annual Meeting of the Organization for Human Brain Mapping; 2022; Glasgow, Scotland, UK.Poster

Individual differences in child and adolescent brain development

Abstract

As more and larger longitudinal, human neuroimaging studies like the Adolescent Brain Cognitive Development℠ Study (ABCD Study®) collect and share data, the field moves closer to population neuroscience. This shift brings significant opportunities to better understand the developing brain, offering unprecedented statistical power and increased generalizability, in addition to challenges new to the human neuroimaging literature.

This work has leveraged that increased statistical power to identify small but significant associations between:

  • Exposure to ambient air pollution and subcortical intracellular diffusion
  • Caregiver acculturation and the mental health of both caregivers and children, in addition to child brain function, in a Hispanic/Latinx subset of participants
  • Callous-unemotional traits and cortical gray matter volume
  • Brain function during response inhibition and pre-adolescent self-regulation

Related ongoing work focuses on the challenges of moving to population-level developmental neuroscience, including the role of individual, environmental, and structural factors that contribute to and/or confound individual variability in child and adolescent brain development.

Manuscripts

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Sukumaran K, Cardenas-Iniguez C, Burnor E, Bottenhorn KL, Hackman DA, McConnell R, et al. Ambient fine particulate exposure and subcortical gray matter microarchitecture in 9- and 10-year-old children across the United States. iScience. 2023 Mar 17;26(3):106087.PLSC CodeAP x cognition CodeAP x emotion Code
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Meca A, Peraza JA, Riedel MC, Musser ED, Salo T, Flannery JS, Bottenhorn KL, et al. Acculturative orientations among Hispanic/Latinx caregivers in the ABCD Study: Associations with caregiver and youth mental health and youth brain function. bioRxiv. 2022 Jan 1;2022.07.24.501248.OSF Project Code Results
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*Waller R, *Hawes SW, Byrd AL, Dick AS, Sutherland MT, Riedel MC, Bottenhorn KL, et al. Disruptive Behavior Problems, Callous-Unemotional Traits, and Regional Gray Matter Volume in the Adolescent Brain and Cognitive Development Study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2020 May 1;5(5):481–9.
*Authors contributed equally to this work.

Presentations

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Bottenhorn KL. Uncovering a latent factor structure underlying pre-adolescent self-regulation and its neural substrates. Poster presentation presented at: Annual Meeting of the Social and Affective Neuroscience Society; 2019 May; Miami, FL, USA. Code Poster